Battling cancer — but only for a profit

This story was making the rounds yesterday, but in case you missed it, the piece is well worth checking out. (via Digby)

It is expected there would be no problems securing funding to explore a drug that could shrink cancerous tumors and has no side-effects in humans, but University of Alberta researcher Evangelos Michelakis has hit a stalemate with the private sector who would normally fund such a venture.

Michelakis’ drug is none other than dichloroacetate (DCA), a drug which cannot be patented and costs pennies to make.

It’s no wonder he can’t secure the $400-600 million needed to conduct human trials with the medicine – the drug doesn’t have the potential to make enough money.

Michelakis told reporters they will be applying to public agencies for funding, as pharmaceuticals are reluctant to pick up the drug.

At roughly $2 a dose, there isn’t much chance to make a billion on the cancer treatment over the long term.

Pharmaceutical research isn’t my area of expertise, but the story explained that DCA has the potential to work wonders, “revitaliz[ing] damaged mitochondria in cancer cells, effectively triggering cell death and shrinking the cells,” which, in turn, means it may effective in treating a variety of types of cancer.

But despite the promise, drug companies aren’t interested. There’s no profit in it. As Digby put it, “And here I thought the pharmaceutical companies had to charge such high prices because of all the research they were doing. Seems without the possibility of future revenue they can’t be bothered. Of course, a cheap cure for cancer would cut into profits in so many ways, wouldn’t it?”

For that matter, it’s also another instance that reminds us of the role the government can play in the sciences.

Ezra explained:

As I’ve said before, using the government’s monopsony and formulary powers to radically reduce the cost of pharmaceuticals probably won’t hurt private R&D much…. But even if it did, pumping those same savings into public sector research and development would more than balance the scales.

So much of the genuinely original molecular research is being done on the NIH’s dime in university labs — but the NIH is underfunded, and so passing on promising and/or risky applications. Pumping cash into their coffers would be a wise, wise investment, and would open promising avenues for research that the drug companies won’t currently pursue.

I’d just add that the free market cannot serve as the be-all, end-all for a society. Values count. The market says this drug is almost worthless, because few stand to make any profit at all. Common sense tells us otherwise.

Of course, it’s a good thing Bush has increased funding for all of that government cancer research, right? Oh wait….

and here i thought the pharmaceutical companies were in business to relieve human suffering and save lives. you mean to say they’re in business to make money?

  • Dr. Michelakis should approach the Bill Gates Foundation as a possible funding source. Seriously, those guys have hundreds of billions of dollars to devote to good causes, and I can’t think of a better one than this to give a few lousy millions to.

  • Good thing Jonas Salk was more interested in preventing polio than making the big bucks. Or many of us in our 50s and 60s now would be crippled or would have died long ago.

    This discovery may be bad news for Big Pharma, but it’s really, really good news for those of us hoping to see Universal health care in our lifetimes. It’s going to take breakthroughs like this and strick bans on smoking, sugar in schools and helmet laws to make it possible for everyone to have quality health care.

  • I am not an expert in this area either but something is not passing the smell test.

    Any drug that ‘has the potential to work wonders’ and has patent protection is worth far more than $2 a dose. It might only cost a few cents or a few dollars to produce but that is true of almost all drugs. The price that the company charges is the price that maximizes profit. Therefore, a drug like this should probably sell for a lot more.

    of course, maybe the drug no longer has patent protection or there is some other reason why there is no profit to be made.

    But it seems like you are missing a significant part of the story.

  • It’s not the pharmaceutical companies responsibilities to test their competitors products. It’s not the McDonald’s responsibility to market Burger King’s products. It’s not Ford’s responsibility to test Toyota’s products. What’s so hard to understand about that? The little news story that the original posts point back to is talking about a substance that’s applied to tumor cells in vitro. There’s absolutely no predicting whether it can be given to a person in some form that will allow it to be delivered to a tumor in adequate dose to have an effect. It sounds promising, but so have a lot of possible treatments in the past.

    Do a Medline search on “aspirin” and “therapeutic trials” and you will turn up over a thousand references. Glaxo isn’t doing those tests either. They are being done under the auspices of NIH, universities, and charities. What do you think that the cancer charities collect all that money for? Better offices for their staff? Oh, yeah, well they do spend it on research, too. I agree that the NIH should be better funded, but I can’t see any reason for the pharmaceutical industry (loathsome though they may be), to be involved.

  • I don’t get it. The drug should be investigated, and the US should do it, but won’t Canada do its own investigation? (the article says that Canadian researchers at the University of Alberta haven’t found funding)

    Their system isn’t capitalist, why wouldn’t they bring it to market if it works?

  • neil wilson, #5 – There’s no patent protection available for this drug. It was previously used for treating metabolic diseases.

  • #7 (RacerX) – “…won’t Canada do its own investigation? (the article says that Canadian researchers at the University of Alberta haven’t found funding)

    Their system isn’t capitalist, why wouldn’t they bring it to market if it works?”

    Unless there was a revolution this morning while I was out getting my kid checked for strep throat, I think that we’re as capitalist here as you are in the U.S. (I mean, I really hope that you weren’t serious with that comment.)

  • DCA, dichloroacetate, has undergone human clinical trials for another application but was found to be toxic – to the point that they discontinued the trials.
    See for example: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16476929&dopt=Abstract

    The U of A researchers have gotten funding for their preliminary work.
    The article about this research, published on the U of A web page,
    doesn’t say if they have applied to government agencies to do clinical
    trials, however based on prior toxicity results it would appear that they
    will have difficulty getting funding for their application.

  • Not that I had to look it up or anything, but…

    Investopedia

    Monopsony

    A market similar to a monopoly except that a large buyer not seller controls a large proportion of the market and drives the prices down. Sometimes referred to as the buyer’s monopoly.

  • Following up on #10, DCA is neurotoxic in people with elevated lactic acid levels and causes liver cancer in rats. To make it as a therapeutic, it would have to be delivered directly to the cancerous tissue or conjugated with some kind of delivery molecule. Both approaches could be protected by patents. The authors of the original finding could have filed a use patent before publishing their results and that would have made it possible for a company to develop DCA as an anti-cancer therapy. Based on the neurotoxicity findings the world is not losing a novel anticancer drug.

  • Standard “approved” chemotherapy is HIGHLY toxic as it is.

    What we have here is a compound that has been around for a long time and has been used medicinally. All that is needed is to find an adjuvant to reduce the side-effects.

    In any event, the ability to make profit should only be allowed to operate where it supports human life and health. Like a cancer cell, if it proves malignant, we may have to endure some discomfort to get rid of it.

  • In response to posting 12 & 13, DCA has been used for about 30 years to treat metabolic syndrome in children. It has proved to be quite safe and toxicity levels are at 600 mg/kg of body weight. So toxic level for an adult weighing 100 kg would be 60,000 mg or 60 grams. The dosage in the report would extrapolate out to about 45 mg/kg which is more than a 10 fold decrease from stated toxic levels.
    Hope this helps

  • I have been searching the WWW for days trying to find a source for DCA. I am dying of liver cancer, and this may be my last shot to stay alive. Does anyone know a source ??
    Reply to: regent@royal.net

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